On Your MARK, Get SET(D2), Go! H3K36me3 Primes DNA Mismatch Repair
نویسندگان
چکیده
Trimethylation of histone H3 on Lys36 (H3K36me3) by SETD2 is linked to actively transcribed regions. Li et al. identify a novel role for H3K36me3 that facilitates DNA mismatch repair (MMR) in cells by targeting the MMR machinery to chromatin during the cell cycle, thereby explaining certain cases of MMR-defective cancers.
منابع مشابه
The Histone Mark H3K36me3 Regulates Human DNA Mismatch Repair through Its Interaction with MutSα
DNA mismatch repair (MMR) ensures replication fidelity by correcting mismatches generated during DNA replication. Although human MMR has been reconstituted in vitro, how MMR occurs in vivo is unknown. Here, we show that an epigenetic histone mark, H3K36me3, is required in vivo to recruit the mismatch recognition protein hMutSα (hMSH2-hMSH6) onto chromatin through direct interactions with the hM...
متن کاملDecoding the histone code: Role of H3K36me3 in mismatch repair and implications for cancer susceptibility and therapy.
DNA mismatch repair (MMR) maintains genome stability primarily by correcting replication-associated mismatches. Defects in MMR lead to several human cancers characterized by frequent alterations in simple repetitive DNA sequences, a phenomenon called microsatellite instability (MSI). In most MSI-positive cancers, genetic or epigenetic changes that alter the function or expression of an essentia...
متن کاملA New Chromatin-Cytoskeleton Link in Cancer.
The set domain containing 2 (SETD2) histone methyltransferase, located at 3p2, specifically trimethylates lysine 36 of histone H3 (H3K36me3). H3K36me3 is an active mark involved in transcriptional elongation and RNA processing and a key regulator of DNA repair. In fact, SETD2 is the only methyltransferase that "writes" the H3K36me3 mark. Recent results from Park and colleagues have found a new ...
متن کاملProteomic analysis of H 3 K 36 me 3 and PSIP 1 / p 75 ( LEDGF ) complexes reveal their wider role in DNA repair
Trimethylation at histone H3 at lysine 36 (H3K36me3) is Background: associated with expressed gene bodies and recruit proteins implicated in transcription, splicing and DNA repair. PC4 and SF2 interacting protein ( ) is a transcriptional coactivator, possesses a H3K36me3 reader PSIP1/LEDGF PWWP domain. Alternatively spliced isoforms of PSIP1 binds to H3K36me3 and suggested to function as adapt...
متن کاملProteomic analysis of H3K36me3 and PSIP1/p75 (LEDGF)
Trimethylation at histone H3 at lysine 36 (H3K36me3) is Background: associated with expressed gene bodies and recruit proteins implicated in transcription, splicing and DNA repair. PC4 and SF2 interacting protein ( ) is a transcriptional coactivator, possesses a H3K36me3 reader PSIP1/LEDGF PWWP domain. Alternatively spliced isoforms of PSIP1 binds to H3K36me3 and suggested to function as adapt...
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ورودعنوان ژورنال:
- Cell
دوره 153 شماره
صفحات -
تاریخ انتشار 2013